wg-quick creates a systemd service for each wireguard config you have. So if you set up a tunel called wg0, you should be able to run ‘sudo systemctl enable wg-quick@wg0’ This will make your tunnel connect on every boot. I have the same setup on my proxmox, so i can reach certain services of my homelab proxied through a root server (the other end of the wireguard tunnel)

Generally, Linux Servers are best administered from a command line. At least in the beginning to set everything up. In turn they are faster on lower hardware as they dont even have a graphical desktop at all so need less resources. You could of course install a windows server OS. They can be fully administered through Remote Desktop and a GUI.

There are multiple projects to make self hosting more accessible (like casaOS). They automate many steps of the setup and then offer you a webUI for further steps. Maybe have a look here https://github.com/awesome-selfhosted/awesome-selfhosted?tab=readme-ov-file#self-hosting-solutions