I had some gaming issues on Gnome, the mouse wouldn’t lock to my main window and it caused all kinds of problems.

Could not find a fix, swapped to KDE Plasma and the issue was gone, I’ve been liking KDE a lot more since, haha.

I had a bit of trouble like that too… Tried Ubuntu and my 2nd display would have static bursts going through the middle horizontally. Couldn’t figure out a fix, tried out Fedora and had no problems.